6th Beilstein Symposium on Experimental Standard Conditions of Enzyme Characterizations (6th ESCEC)

Venue: Hotel Jagdschloss Niederwald

Location: Ruedesheim/Rhein, Hessen, Germany

Event Date/Time: Sep 16, 2013 End Date/Time: Sep 20, 2013
Abstract Submission Date: Jun 28, 2013
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Description

...Celebrating the 100th Anniversary of Michaelis-Menten Kinetics

In 1913, based on sound experiments and analytical calculations of invertase activity Leonor Michaelis and Maud Menten had proposed the concept of affinity constant which later was called Michaelis-Menten constant. The impact of their work is noteworthy since it laid the groundwork for modern enzymology reaching from pathway investigations and metabolic simulations to systems biology. Over the decades methods and techniques have been developed to obtain huge amounts of experimental data from myriads of enzymes that were published in written papers and stored in databases.

The other side of the coin is that by applying this data in systems biology studies it became obvious that the usefulness of functional enzyme data in both the literature and the databases is severely limited due to the fragmentation and incomplete description of materials and methods. Since this situation can cause difficulties to interpret and reproduce published data, almost ten years ago the STRENDA (Standards for Reporting Enzymology Data) Commission took over to address the improvement of the reporting quality of functional enzyme data in order to support the community with the efficient application of enzyme kinetics in the in vivo, in vitro and in silico investigation of biological systems. The STRENDA Guidelines are the result of extensive consulting sessions with the scientific community and are recommended today by more than 30 biochemistry journals.

This 6th ESCEC Symposium provides a platform not only to commemorate Michaelis-Menten kinetics (and some additional scientific landmarks) but also to bring together experts from all fields of modern enzymology and metabolic network investigation to present and discuss new results, approaches and methodologies including the following topics:

  • Systems Biology and Systems Medicine: the new kids on the block,
  • Sequence, Structure, Kinetics, Control and Regulation,
  • Physiological Meaning of Enzyme Kinetics,
  • Network kinetics versus enzyme kinetics,
  • Enzymes in Metabolic Collaboration,
  • Pitfalls in Data Reproduction,
  • The end to the tower of Babel: making biochemist speak a lingua franca.

Venue

Jagdschloss Niederwald 1
Hessen
Germany
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Conference Speakers

Speakers include:

  • Karen Allen (Boston, MA, USA)
  • Richard Armstrong (Nashville, TN, USA)
  • Patricia Babbitt (San Francisco, CA, USA)
  • Maria Luz Cardenas (Marseille, France)
  • Athel Cornish-Bowden (Marseille, France)
  • Holger Dobbek (Berlin, Germany)
  • John Gerlt (Urbana, IL, USA)
  • Roger Goody (Dortmund, Germany)
  • P. Fred Guengerich (Nashville, TN, USA)
  • Manfred Konrad (Göttingen, Germany)
  • Thomas Leyh ( Bronx, NY, USA)
  • Monica M. Palcic (Copenhagen, Denmark)
  • Frank Raushel (College Station, TX, USA)
  • Dietmar Schomburg (Braunschweig, Germany)
  • Gertien Smits (Amsterdam, The Netherlands)
  • Reiner Sterner (Regensburg, Germany)
  • Keith Tipton (Dublin, Ireland)
  • Nicholas Turner (Manchester, UK)
  • Hans Westerhoff (Amsterdam, The Netherlands)
  • Chris Whitman (Austin, TX, USA)
  • Jan-Olof Winberg (Tromsö, Norway)

Additional Information

Speakers include:

  • Karen Allen (Boston, MA, USA)
  • Richard Armstrong (Nashville, TN, USA)
  • Patricia Babbitt (San Francisco, CA, USA)
  • Maria Luz Cardenas (Marseille, France)
  • Athel Cornish-Bowden (Marseille, France)
  • Holger Dobbek (Berlin, Germany)
  • John Gerlt (Urbana, IL, USA)
  • Roger Goody (Dortmund, Germany)
  • P. Fred Guengerich (Nashville, TN, USA)
  • Manfred Konrad (Göttingen, Germany)
  • Thomas Leyh ( Bronx, NY, USA)
  • Monica M. Palcic (Copenhagen, Denmark)
  • Frank Raushel (College Station, TX, USA)
  • Dietmar Schomburg (Braunschweig, Germany)
  • Gertien Smits (Amsterdam, The Netherlands)
  • Reiner Sterner (Regensburg, Germany)
  • Keith Tipton (Dublin, Ireland)
  • Nicholas Turner (Manchester, UK)
  • Hans Westerhoff (Amsterdam, The Netherlands)
  • Chris Whitman (Austin, TX, USA)
  • Jan-Olof Winberg (Tromsö, Norway)