EMBO | EMBL Symposium: Frontiers in Metabolism: From Molecular Physiology to Systems Medicine (EES14-06)
|Event Date/Time: Nov 17, 2014||End Date/Time: Nov 20, 2014|
|Abstract Submission Date: Jul 10, 2014|
Conversion and processing of small molecules by cellular metabolic networks provides the cell with the necessary nutrients, biomass precursors and energy resources. Metabolism has therefore traditionally been seen as a downstream effector layer in the regulatory architecture of the cell. Recent work, however, revealed that metabolism commands cellular and organismal physiology and is closely intertwined with multiple signaling pathways.
Studies on the mechanisms of metabolic sensing, characterization of the system-level impact of metabolism on regulatory networks and discovery of new metabolic coordination mechanisms have provided unforeseen insights into the crosstalk between metabolism and cellular homeostasis, which show a remarkable evolutionary conservation.
This very active field of investigation is interdisciplinary in nature and requires a variety of approaches, from investigations at the molecular and cellular levels to system-wide genetic and integrative approaches in multiple species. This Symposium will therefore bring together leading researchers from a variety of disciplines and disease areas to stimulate cross-fertilizing discussions and exchanges.
The purpose of this symposium is to offer an integrated view of metabolism and highlight the emerging concept that metabolism exerts an important homeostatic role on multiple pathways involved in human disease, including tumor cell growth, inflammation, neuronal functions and epigenetic reprogramming.