Improving Solubility & Formulation of Proteins & Peptides

Organization: Fleming Europe

Event Date/Time: Mar 07, 2013 End Date/Time: Mar 08, 2013
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Solubility is a key to drug efficiency. Solubility characteristics of 40–70% of new drug candidates are so poor that they cannot be formulated on their own. There is a great need for new formulation methods and strategies to increase solubility. Low solubility is associated with poor absorption, which affects bioavailability. Unfavorable oral bioavailability is an important reason accounting for the failure of the drug candidates. Considering the lack of in vitro high-throughput screening assay for oral bioavailability, it is critical to develop in silico models for early predictions of oral bioavailability.



Fleming Europe

Additional Information

At our Masterclass you will:

  • predict protein solubility within in silico methods
  • understand the viability of in silico compared with experimental results
  • study the physico-chemical mechanisms of insolubility and aggregation
  • learn about predictive experiments for solubility and aggregation
  • explore formulation and delivery aspects - aiming to increase solubility
  • gain insights into latest strategies to increase protein solubility and improve efficacy