Keystone Symposia: The Ubiquitin System - From Basic Science to Drug Discovery (A2)

Organization: Keystone Symposia on Molecular and Cellular Biology


Location: Big Sky, Montana, United States

Event Date/Time: Jan 07, 2014 End Date/Time: Jan 12, 2014
Abstract Submission Date: Oct 24, 2013
Report as Spam


The conference will:

• Focus on the ever-increasing range of cellular contexts in which ubiquitination plays a part and include updates on clinically-oriented studies relating to neurodegeneration, mitochondrial dysfunction and inflammation/infection;

• Incorporate two technology-focused workshops led by established international experts that focus on technological advances and the development of model systems for interrogating the ubiquitin system;

• Provide a balance of exciting science and room for discussion to foster collaborations between clinicians, translational researchers and basic scientists with interests ranging from the biophysics to the cellular biology of the ubiquitin system.

Session topics:

• Ubiquitin Chains and Modifications • Ubiquitin Proteasome System Enzymes: Structural Insights and Biophysical Mechanisms • Ubiquitin-Like Proteins in Cellular Signaling • Regulation of Signaling Pathways by the Ubiquitin Proteasome System • Ubiquitin Ligases in Cellular Signaling • Deubiquitinase Enzymes in Cellular Signaling • The Ubiquitin Proteasome System as a Drug Target • The Ubiquitin Proteasome System in Disease plus two workshops on the ubiquitin proteasome system


Iannis Aifantis, HHMI/New York University School of Medicine, USA James Brownell, Takeda Pharmaceuticals Inc, USA Heran Darwin, New York University School of Medicine, USA Raymond J. Deshaies♠, California Institute of Technology, USA Ivan Dikic, Goethe University Medical School, Germany Vishva M. Dixit, Genentech, Inc., USA Daniel J. Finley, Harvard University, USA Marcus Groettrup, University of Constance, Germany Steven P. Gygi*, Harvard Medical School, USA Ronald T. Hay, University of Dundee, UK Alain Israël, Institut Pasteur, France Stephen P. Jackson, University of Cambridge, UK Christopher Kirk, Onyx Pharmaceuticals, USA Rachel Klevit, University of Washington, USA David Komander, MRC Laboratory of Molecular Biology, UK Christopher D. Lima, Memorial Sloan-Kettering Cancer Center, USA Gwen Nichols, Hoffmann-LaRoche, USA Matthias Peter, ETH Zürich, Switzerland Hidde L. Ploegh*, Whitehead Institute for Biomedical Research, USA Simona Polo, FIRC Institute of Molecular Oncology, Italy Michael Rape, University of California, Berkeley, USA Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA Brenda A. Schulman, St. Jude Children's Research Hospital, USA Titia K. Sixma, Netherlands Cancer Institute, Netherlands Henning Walczak, UCL Cancer Institute, UK Wenyi Wei, Beth Israel Deaconess Medical Center, USA Ingrid E. Wertz, Genentech, Inc., USA Cynthia Wolberger, Johns Hopkins University School of Medicine, USA

♠Keynote Speaker  


Big Sky
United States


Keystone Symposia on Molecular and Cellular Biology