Venue: Hilton San Diego Resort

Location: San Diego, California, United States

Event Date/Time: Feb 14, 2001 End Date/Time: Feb 16, 2001
Paper Submission Date: Jan 05, 2001
Report as Spam


Combichem programs face the challenge of meeting the demand of HTS for growing numbers of compounds, while still meeting the critical criteria of more novel chemistries and structures, less overlap with existing libraries, more druglike properties, greater purity, and lower cost. These factors play an important role as HTS speeds rise and as the number of genomically derived targets explode. New resins and linkers offer easier, faster, and more practical synthetic methodologies for compound synthesis in manual, semiautomated, and automated approaches increasing the synthesis throughput as well as compound purity. Novel chemistries and reaction strategies, particularly for building blocks, will be key to extending the range of diversity produced, while still keeping costs low. Increased demand for compound/library purity and more rigorous QC demands high-throughput purification protocols impacting the turnaround compound/library production timeframe with the benefit of generating reliable screening data feedback for lead follow-up. This conference will provide you with plenty of new information about the details of combinatorial and parallel synthesis, so plan to attend.