Gene Delivery Systems - Improving pathways, efficiency and stability

Venue: Hilton Washington

Location: Washington, District Of Columbia, United States

Event Date/Time: Dec 06, 2001 End Date/Time: Dec 07, 2001
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An increasing demand for gene therapeutic products has caused a rapid evolution of gene transfer technologies. Specific tissue targeting, immune responses and system stability are major factors in selecting and developing a novel tool for gene transfer. While more genes are being identified, the challenge of utilizing efficient and specific DNA delivery systems remains a primary area of research and development.

Join our international panel of experts who will discuss specific advantages and disadvantages of gene delivery systems currently available as they relate to:

Physical Methods
- effectiveness and toxicity
- stabilization of nonviral vectors
- ultarasound mediated delivery
- bile duct mediated delivery to liver

Polymers in Gene Delivery
- polyethylenimines
- cyclodextrin based polymers
- histidine and lysine (HK) polymer
- glycotargeted delivery sytems
- porus polymer microspheres

DNA Vectors
- P element transposon
- Plasmid DNA and immune responses

Viral Gene Delivery
- Adenoviral Vectors, AAV, Lentiviral Vectors
- Modified Vaccinia Ankara (MVA) viral vector
- Surface modification with polymers

Liposomes/ Cationic lipids
- systemic delivery of cationic liposome based complexes
- liposome encapsulation technology
- stabilized antisense-lipid particles

Patent and FDA requirements
- FDA advisory committee on Gene Delivery Systems
- Requirements for patent applications


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