Orphan & Nuclear Receptors: Strategies for New Therapeutic Interventions

Venue: Holiday Inn on the Bay

Location: San Diego, California, United States

Event Date/Time: Jun 27, 2002 End Date/Time: Jun 28, 2002
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Detailed agenda available at our website.

Post - Conference Half-Day Workshop : Ligand Identification & Screening Technologies

Main Conference:

Due to the significant physiological role, nuclear and orphan receptors are emerging targets for drug discovery beyond functioning as transcription factors.

Enhancing or inhibiting the effect of nuclear receptors or structural changes of their ligands is of significant importance. This has a tremendous influence on the metabolic pathways of diseases such as diabetes, heart diseases or cancer. A greater understanding of nuclear receptors and their interactions is important for developing drugs with fewer side effects.

This conference will discuss the effects of nuclear receptors in lipid metabolism, the role of orphan receptors in xenobiotic metabolism and the relationship between nuclear receptors and tumor cells. Furthermore, the newest developments on receptor modulators and co-activators will be presented.

International experts from industry and academia provide you with the latest findings on:

- PPAR and Atherosclerosis
- The role of PPAR in Insulin Resistance and Dyslipidemia
- 27- Hydroxycholesterol as an Endogenous LXR Ligand
- CAR in Adaptive Expression of Genes in Response to Drugs
- Novel Functions of SXR in Xenobiotic Metabolism
- RXRa in Hepatocytes - Functional Role
- Retinoids in Cancer Therapy
- LXRa and FXR and their Role in Malignancy
- Progesterone Receptor Modulators
- VDR - Importance of a Ligand Shape for the Protein's Function
- Engineering Orthogonal Ligand-Receptor Pairs