Frustration with the lack of drugs entering the market has forced the pharmaceutical industry to examine how libraries are designed and synthesized. Emphasis has shifted from making large combinatorial libraries to smaller, more target-focused libraries, filtered to exclude non-drug or non-leadlike entities. This has been facilitated largely by increased knowledge of biological target structure, in conjunction with advances in computational tools. Combichem techniques are now being used more frequently in medchem projects and yielding results in lead discovery and optimization. Efforts to produce diverse natural product-like libraries in the hope of finding compounds that will be more effective in the clinic are also gaining a great deal of attention. Compound storage and stability are critical issues for many organizations that handle large compound collections. All of these topics will be discussed at length during this event. This conference will include a one-day special event showcasing results from microwave-assisted synthesis in organic, medicinal, and combinatorial chemistry. Presentations will be given by key industrial and renowned academic players in this new exciting field.

Advisory Committee To read related articles on
Advancing Library Design
and Organic Synthesis
from Current Drug Discovery's
March 2002 issue, click here


Sponsoring Publications:
Advances in Lead Optimization
Current Drug Discovery
Drug Discovery and Development
Elsevier Science
Genome Research
Kluwer
PharmaGenomics
Physiological Genomics
Wiley-VCH

Web Partners:
Combichem.net
HTScreening.net
Processdevelopment.net

Dr. Prabhat Arya, National Research Council of Canada
Prof. Hicham Fenniri, Purdue University
Dr. Adam Golebiowski, Procter & Gamble Pharmaceuticals
Dr. Timothy Herpin, Bristol-Myers Squibb Company
Dr. C. Oliver Kappe, Karl-Franzens-University Graz
Dr. Christopher A. Lipinski, Pfizer Global Research and Development
Dr. Aubrey J. Mendonca, Polymer Laboratories Inc.
Dr. David Portlock, Procter & Gamble Pharmaceuticals
Prof. Herbert Waldmann, Max-Planck-Institut für Molekulare Physiologie





Sunday, February 23, 2003


1:30-2:00 Preconference Tutorial Registration

2:00-5:00 Preconference Tutorial: Electronic Notebooks
Sponsored by:

Dr. Rich Lysakowski, Executive Director/Chief Science and Technology Officer, Collaborative Electronic Notebook Systems Association (CENSA)
Collaborative Electronic Notebook Systems Association (CENSA) aids in the innovation, convergence, and integration of technologies for building Collaborative Electronic Notebook Systems (CENS) and more advanced systems for R&D team project data management, collaboration, and recordkeeping.



4:00-5:30 Early Conference Registration

Monday, February 24