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| Email |
visionresearch@ntlworld.com
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| Category |
Science: Life_Sciences
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| Description |
The Retinoid Cycle describes phenomena involved in metabolism and transport of retinoids from the outer segments across the IPM to the RPE and back to the outer segment where rhodopsin is reconstituted. Recent progress in identification of components involved in recycling of retinoids has been unprecedented. Mutations in their respective genes have been shown to lead to disruption of the retinoid cycle and in many cases to human retina disease including retinitis pigmentosa, choroidal sclerosis, cone/rod dystrophy, macular degeneration, among others. The purpose of the meeting is to summarize current knowledge regarding mechanisms of photobleaching in rods and cones, and the metabolism of retinoids in photoreceptors and the RPE. Particular emphasis will be given to explore gene defects leading to human retina disease, and to investigate naturally occurring and laboratory generated animal models for these diseases.
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