Event Date/Time: Jun 21, 2004
End Date/Time: Jun 22, 2004
Computational methods are leading the "New Biology", the emerging discipline in which all biological parameters are interconnected. In this new discipline, biological pathways can be constructed through the use of computational algorithms to generate meaningful data from gene expression microarrays, mass spec, 2-D gel, protein-protein interaction studies, and other experiments. This will enable us, in addition to understanding how parameters are interconnected, to identify therapeutically relevant targets, and define and diagnose disease on a molecular basis. The analysis of tissue-specific assays to test compounds may allow a more accurate prediction of drug response than animal studies that are often poor and inconsistent predictors. Architectures of data underlie the accurate diagnosis and early intervention of disease based on genotype, gene expression signatures and protein transcription. This knowledge will help deliver personalized medicine and lower the cost of drug development.