Event Date/Time: Nov 15, 2004
End Date/Time: Nov 16, 2004
Visualizing the activity of both drugs and targets in the context of a living cell are critical to the effective evaluation of drug action and efficacy. Green Fluorescent Protein (GFP) is a fluorescent probe that attaches to a protein of interest, and allows real-time, non-invasive and representative reporting in living cells. Using GFP as a reporter gives a new window into the machinery of a cell, and allows the selection and investigation of compounds that address specific biochemical pathways. The applications of GFP in drug discovery allow powerful insights into cellular imaging, early stage target characterization, receptor biology, protein-protein interaction, HTS/HCS screening assays, and in vivo diagnostics. GFP has proven to be instrumental in observing and monitoring the effects of RNAi and gene knock-down on biochemical pathways. The advantages of using GFP are numerous- come to the conference to hear about the latest constructs and applications of this reporter molecule and how it can enable you to improve your success rate in evaluating drug candidates.