Considering the risks and costs of new drug development, it is critical to eliminate high-risk leads as early as possible. Computational (in silico) screening has become a valuable tool to predict the interaction of a compound with the biological system. Absorption, distribution, metabolism, excretion and toxicology are all important issues to consider when developing accurate and predictive models. Conveniently co-located, these conferences review techniques and strategies for developing faster and yet more accurate models to predict the ADME and Toxicology of new lead compounds.