8th International Conference on Drug-Drug Interactions (DDI-2005)

Venue: Bell Harbor Conference Center

Location: Seattle, Washington, United States

Event Date/Time: Jun 13, 2005 End Date/Time: Jun 17, 2005
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8th International Conference on Drug-Drug Interactions:
New Technologies, Clinical Approaches, Prediction and Mechanisms for the Evaluation of Drug-Drug Interactions

June 13-17, 2004; Bell Harbor Conference Center, Seattle, WA, USA

1. New technologies and approaches for the evaluation of drug-drug interaction (DDI)

-in vitro and in vivo models (transgenic cell lines and animals)
-recombinant enzymes (including preclinical species)
-modeling of the enzymes and transporters (crystal structure-based homology modeling and computational approaches)
-high throughput assays
-development of analytical and automated approaches

2. Current status of clinical drug-drug interaction

-most recent case studies of clinical DDI including significant changes in PK and PD leading to severe adverse effects

3. Pharmacokinetic drug-drug interaction and its prediction from in vitro ADME data

-inhibition and induction-mediated DDI of CYP, Phase II enzymes and transporters
-approaches to predict in vivo PK from in vitro kinetic data (reversible and irreversible CYP inhibition)
-clinical application of probe substrate for DDI evaluation
-genetic polymorphism of enzyme and transporters

4. Mechanisms of drug-drug interaction

-Enzyme kinetics
-mechanism-based inhibition
-sequential metabolism kinetics
-reactive metabolites


Pier 66 - 2211 Alaskan Way
United States

Additional Information

Registration fee: $1500.00