CHI’s Inaugural Pathway Analysis

Venue: San Francisco

Location: San Francisco, California, United States

Event Date/Time: Apr 20, 2005 End Date/Time: Apr 22, 2005
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Twelfth Annual Human Genome Discovery and Ninth Annual Gene Functional Analysis
Expression profiling is driving the pharmaceutical R&D process. It is being used downstream of target identification, as a biological readout for target modulation. Targets first identified through genomics then need to go through validation testing, to see if a phenotypic change occurs when a target is disregulated. These targets or pathways can be modified by using either RNAi, or the use of a chemical ligand that interacts with a target. The results are compared in order to understand a compound’s activity for on- and off- target effects. Pathway elucidation is critical to this process, in order to both identify the biochemical components in a pathway associated with disease, and the affect of a chemical entity on this pathway. This synergistic approach will help to identify ways to validate and prioritize targets, and enable us to understand the molecular mechanism of therapeutics.