CHI’s Sixth Annual Recombinant Antibodies

Venue: Cambridge

Location: Cambridge, Massachusetts, United States

Event Date/Time: May 18, 2005 End Date/Time: May 19, 2005
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The design of protein therapeutics involves extensive knowledge of the structural and functional properties of proteins and peptides, how they interact with nucleic acids and proteins, form complexes, and ultimately impact pathways involved in disease. Optimizing protein drugs through protein medicinal chemistry involves improving the stability of peptides/proteins and their delivery, while addressing issues around immunogenicity, toxicity, and aggregation. Novel approaches will be highlighted in this meeting that are aimed at finding solutions to these challenges. Phage and other related techniques such as mRNA, bacteria, yeast, antibody, ribosome display offer the ability to generate and select ligands against targets, and engineer drug-like properties into candidates that show high affinity and specificity. Case studies will be showcased of successful drugs that have been created using these approaches.