| Description |
The 1st Cuban Workshop on Genomics and Community Genetics is aimed to teach the participants both theoretical basis and practical applications of human genetics and molecular biology methods. The main goal is to stimulate basic research in these fields in Central and South American and the Caribbean countries. The workshop also intends to encourage the development of local and regional laboratories where different human samples will be collected and analyzed for genomic and genetic studies. The workshop has been planned as an international forum for scientific exchange on all major areas of human genetics, with an opportunity for each of the participants to exchange views on the present state of knowledge, the emergence of new concepts and the development of innovative techniques relevant to regional problems. The 1st Cuban Workshop on Genomics and Community Genetics will include a series of lectures on Community Genetics, a range of tutorials and a practical course embodying cutting-edge technology. The workshop is intended for students and researchers with limited experience in using different tools for genetic, genomics and bioinformatics methods.
The 3rd Workshop on Genomic Research is organized to review the state of the art on Genetics and Genomic of Complex Traits (High Blood Pressure, Schizophrenia, Autoimmune Diseases), Study Design for Complex Traits, HLA typing and Disease Association, SNPs, Haplotyping and Pharmacogenomics, Databases, Bioinformatics and Statistical Analysis.
Main Topics
Lecture topics have been selected that have an emphasis on genomics and community genetics appropriate to the region. These will include:
1. Human population genetic structure/substructure, founder effect, drift, endogamy, consanguinity
2. Genetic determinants of reproductive success/failure
3. Molecular cytogenetics
4. Single gene defects, especially the haemoglobinpathies/ thalassaemias
5. Genetic predisposition to disease (hypertension, diabetes, etc)
6. Host susceptibility to infectious disease (SARS, AIDS, TB, Leprosy, etc)
7. The genetics of blindness and deafness, and genetic factors in intellectual disability
8. Common congenital disorders, e.g. cleft lip and palate
9. Cancer genetics
10. Diseases of adult-onset
11. The design of community-based education and counseling programs/community involvement in the prevention of genetic disease
12. Establishment of disease registers/screening programs for diseases of high local/regional/community prevalence.
13. Ethical issues of human genetics.
Tutorials will be held, which will describe:
1. Introduction to human genetics on the internet (NCBI, ENSEMBL, OMIM, GENECARDS ETC...)
2. Pedigree creation using PROGENY and Cirille software
3. Genome and population data analysis: introduction to population structure and differentiation, migration inference and genetic distance matrix (ARLEQUIN software and others
4. Linkage analysis including - parametric methods (two-point and multipoint analysis); allele sharing (nonparametric) methods for sib-pairs and extended families (two-point and multipoint analysis), fine mapping, linkage admixture, association studies (trios and case control, sample size estimation (extended families [simulation studies], sib-pairs and case-control data) and estimating empirical p-values. Introduction to GENEHUNTER/ALLEGRO and LINKAGE/FASTLINK software
5. Medical diagnosis, questionnaires and blood sample collection and witness preservation.
6. Genomic DNA purification, evaluation, amplification and preservation.
7. HLA genotyping by SSP, SSO – PCR and sequencing.
8. Bioinformatics
Practical classes will include:
Genomic DNA purification, evaluation, amplification and preservation, PCR, real-time PCR, SSCP, HLA genotyping by SSP, SSO – PCR and sequencing, gene sequencing, cytogenetics (including FISH), SNP analysis by sequencing and cell culture, Bioinformatics and data handling
Confirmed Speakers
Name Country Affiliation
Baralle, Francisco Italy Director-General, ICGEB
Baralle, Diana UK Addenbrookes Hospital, Cambridge
Bittles, Alan Australia Centre for Human Genetic
Loveland, Jane UK Welcome Trust Sanger Institute
Moore, Dominic USA UNC Lineberger Comprehensive Cancer Center
McElreavy, Ken France Pasteur Institute
Oglesbee, Steve USA UNC Lineberger Comprehensive Cancer Center
Parra, Esteban Canada Universidad de Toronto
Patrinos, George Netherland Erasmus Medical Center, Rotterdam
Patton, Michael UK St George's Hospital Medical Medical School
Saggar, Anand Canada St George's Hospital Medical School
Schmidt, Wolfgang M. Austria University of Viena
Tilanus, Marcel G.J Netherlands Dept. of Pathology, Utrech
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