Molecular Mechanisms of Resistance to Antibiotics, Drugs and Pesticides (Resistance 2007)

Venue: Churchill College, Cambridge University

Location: Cambridge, United Kingdom

Event Date/Time: Apr 16, 2007 End Date/Time: Apr 19, 2007
Registration Date: Apr 16, 2007
Abstract Submission Date: Oct 02, 2006
Paper Submission Date: Oct 02, 2006
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Aims of the Conference

This meeting will focus upon the mechanisms by which pathogens and agricultural pests resist the action of drugs and chemical control agents. The conference aims to bring together scientists from academic and industrial backgrounds engaged in the study of resistance mechanisms; in the identification and diagnosis of resistant organisms, in monitoring and managing the dissemination of resistance and in applying this knowledge to development of new pharmaceuticals and agrochemicals that overcome the problem of resistance. The meeting will be organised jointly by the SCI Bioactive Sciences and Pest Management groups.

Themes and Call for Papers

Sessions will focus on resistance mechanisms in four biochemical areas:

Biosynthetic pathways
Biosynthetic pathways continue to provide a rich source of targets for antimicrobials, antifungals and herbicides. The session will focus on the emergence and biochemical characterisation of resistance mechanisms in primary metabolic pathways and the means by which new agents may overcome these.

Energy production
The success of broad spectrum agents that interfere with energy production in mitochondria or chloroplasts, highlights the need to define resistance mechanisms to ensure continued useful targeting of these core
biochemical pathways.

Transport across membranes and cell walls
Both active efflux mechanisms and alterations in cell permeability play a key role in resistance to a wide range of antimicrobials and insecticides. Presentations will focus on new insights into resistance stemming from the rapid recent advances in membrane protein biochemistry and on new agents that avoid or inhibit resistance arising from altered transport mechanisms.

Defining molecular resistance mechanisms to channel blockers and acetyl choline esterase inhibitors provides the framework for the discovery of novel chemistries active against insect nerve transmission

The conference will link these core topics to developments in the areas of:

Resistance to antiviral agents
We invite presentations describing progress towards understanding of resistance mechanisms operating in all viral classes, as well as results showcasing new antiviral agents that circumvent or reduce these effects.

Resistance in vector borne diseases
Resistance of vector borne diseases such as, but not limited to, malaria, are causing world-wide health problems with resistance now found to many of the major drugs types. This session will be used to describe such cases and provide incite into current management programmes.

Molecular diagnosis and resistance monitoring
Understanding and managing the spread of resistance mechanisms is underpinned by the development of rapid diagnostic methods that define the spread of resistance, and the effectiveness of strategies to combat it.

Evolution of prokaryotic resistance mechanisms
The intense selective pressure imposed by widespread antibiotic use has stimulated the emergence and dissemination of a wide variety of spontaneous and acquired genetic modifications that confer resistance to single or multiple antimicrobial classes. The session will highlight the most recent findings on the emergence, mobilisation and dissemination of resistance genes and genetic elements in pathogenic bacteria.

Closing Date for submission of Abstracts: October 1st 2006


Additional Information

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