Non-clinical Testing of Vaccines

Venue: Crowne Plaza Amsterdam City Centre

Location: Amsterdam, Netherlands

Event Date/Time: Jun 04, 2007 End Date/Time: Jun 06, 2007
Report as Spam


During the last decade, the development of vaccines has been rationalised. With the increase in knowledge of the immune system there are important changes in the way of thinking. The relationship between the innate and adaptive immunity has been changed after the recognition of the Toll-Like Receptors and the balance between Th1 and Th2 cells has become a critical parameter in the discussion.
The purpose of the meeting is to look at this data from a 21st century perspective and to get agreement on the most important issues for nonclinical development in our current understanding of vaccines. For many vaccines the final proof of action cannot be obtained in the clinical situation, unless large epidemiological studies are carried out. For these vaccines, the proof-of-concept has to rely therefore on animal experimentation (The Animal Rule).
Another important issue is the development of therapeutic vaccines, especially in cancer treatment. Again proof-of concept data is difficult to obtain and the classical humoral endpoint of the antibody titre is not sufficient as a secondary endpoint.
The meeting will discuss these items in depth and develop recommendations for industry and regulatory authorities.


Nieuwezijds Voorburgwal 5