American Chemical Society Prospectives: Mechanisms of Chemically-Induced Toxicity for Medicinal Chem (ACS Toxicity)

Venue: Sheraton Society Hill

Location: Philadelphia, Pennsylvania, United States

Event Date/Time: May 18, 2008 End Date/Time: May 20, 2008
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ACS ProSpective Conferences
Mechanisms of Chemically-Induced Toxicity for Medicinal Chemistry

May 18 - 20, 2008 | The Sheraton Society Hill| Philadelphia, PA
Conference chairs F. Peter Guengerich, Professor of Biochemistry and the Director of Vanderbilt’s Center in Molecular Toxicology, and Dr. James MacDonald, EVP of Preclinical Development at the Schering-Plough Research Institute, have developed this program to cover the chemical basis of toxicity as it applies to medicinal chemistry.

Sessions will be held on reactive metabolites and alternative mechanisms, with an emphasis on specific chemical groups and methods of screening. Numerous case studies will be given throughout the program by scientists from Pfizer, Schering Plough, and Merck, among others.

The conference will also cover some newer methods and even future approaches to assessing the toxicity potential of compounds in humans, including “omics” approaches, and will provide a view of the current regulatory environment -- and therefore the level of likely acceptance of those methods.

On Sunday, a one-day short course will be offered, designed to get participants up to speed on the subject matter that the conference covers. Topics will include: the essentials of drug metabolism and pharmacokinetics; enzymes involved in drug metabolism (both human & animal) and their relevance to drug interactions and toxicity; covalent binding, and an overview of related biology and its relevance to toxicity; and examples of approaches with drugs: defining mechanisms, developing new screens, and using chemical synthesis to improve the probability of success.


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