Autophagy: from molecules to disease

Venue: Royal Agricultural College, UK

Location: Cirencester, United Kingdom

Event Date/Time: Sep 08, 2010 End Date/Time: Sep 12, 2010
Early Registration Date: Jul 07, 2010
Abstract Submission Date: Jul 07, 2010
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Description

Autophagy is an important catabolic process that contributes to cell survival, cell growth and cell differentiation, in model cell systems and in whole organisms. It is implicated in a number of human diseases including cancer, bowel disease and neurodegeneration, and has also been shown to play important roles in infectious disease. Autophagy is a degradative pathway which requires the formation of a special double membrane vesicle (the autophagosome) to sequester and deliver components to the lysosome. Over recent years our understanding of the basic mechanisms of the process – including the signalling pathways involved and the mechanisms of autophagosome biogenesis, maturation and trafficking – has evolved rapidly. Furthermore, the recent data implicating autophagy in human diseases has catalysed and developed widespread, cross-disciplinary interest. This Harden Conference will focus on basic mechanisms and disease processes, and will highlight the most recent advances in the field.

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