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In the past decade, clinical and laboratory research has focused on the role of myeloid cells in cancer, sepsis, inflammation, infections, trauma, and autoimmunity. A previous meeting that took place in Tampa, FL, USA, has demonstrated that this area of research is of high interest to a broad scientific community. There is now significant evidence supporting a role for myeloid cell expansion and activation in the regulation of T-cell number and function, which appears to be a common element to the inflammatory responses in the pathobiology of disease. These cells include hematopoietic progenitor cells, myeloid-derived suppressor cells (MDSC), regulatory dendritic cells, as well as macrophages. Several clinical trials have been established to pharmacologically manipulate the expansion or activation of these cells with the goal of regulating a patients’ immune response. These studies have targeted multiple clinical indications including cancer via the down regulating of myeloid cell number and function, as well as inflammatory conditions whereby the number and activation of these cellular suppressors are up-regulated.
The goal of this conference is to bring together scientists and clinicians from the diverse fields in which myeloid cells have a critical role, to discuss their expansion, bio-distribution, trafficking, differentiation, regulation, and function. We expect that this conference will engender productive discussions, novel hypotheses and will foster new collaborations, all of which are critical to the development of this exciting new field.
The invited speakers provide the framework for the meeting, but the primary emphasis will be speakers selected from submitted abstracts. This is further supported by two poster sessions and three extended oral sessions established for presentations by speakers selected from submitted abstracts.
This symposium is organised by Elsevier in celebration of the 10th year of publication of International Immunopharmacology. Thus, all speakers, both invited and selected from abstracts will be encouraged to submit a manuscript on the topic of their presentation for publication in a special issue of the journal. We invite everyone to join us in October 2010 for this exciting meeting.
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