Keystone Symposia: Functional Consequences of Structural Variation in the Genome

Venue: Sheraton Steamboat Resort

Location: Steamboat Springs, Colorado, United States

Event Date/Time: Jan 08, 2011 End Date/Time: Jan 13, 2011
Registration Date: Jan 08, 2011
Early Registration Date: Nov 08, 2010
Abstract Submission Date: Oct 11, 2010
Report as Spam


Sequencing of genomes has led to the discovery of a spectrum of both small-scale and large-scale genetic variation among individuals. Changes in copy-number and genome structural variation are common in most mammalian species and affect a wide range of phenotypic traits. The goal of this symposium will be to explore the relative impact of structural variation to common and rare human genetic diseases; discuss our understanding of ‘normal’ patterns of structural variation and its origin based on examining additional human genomes using new sequencing technologies; explore the extent of intraspecific variation in other organisms and their importance in phenotypic traits; and discuss the adaptive importance of this form of variation during the evolution of mammalian species.