Keystone Symposia: Inositide Signaling in Pharmacology and Disease

Venue: Keystone Resort

Location: Keystone, Colorado, United States

Event Date/Time: Feb 13, 2011 End Date/Time: Feb 18, 2011
Registration Date: Feb 13, 2011
Early Registration Date: Dec 14, 2010
Abstract Submission Date: Oct 14, 2010
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Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.