Event Date/Time: Dec 07, 2010
End Date/Time: Dec 07, 2010
This masterclass will examine the solubility and supersaturation of drugs from a solution chemistry point of view. We will explain how solubility is affected by molecular structure, pH, pKa and salt formation, and discuss the role of lipophilicity. We will discuss the relationships between solubility and dissolution, and lipophilicity and permeability, and then look at techniques for enhancing solubility and supersaturation by the use of additives.