Structural Biology and Drug Discovery Conference 2010

Venue: The Ocean Coral

Location: Puerto Morelos, Mexico

Event Date/Time: Dec 04, 2010 End Date/Time: Dec 07, 2010
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Description

Knowledge of the sequence of human and pathogen genomes, together with the three-dimensional structures of protein targets, has the potential to accelerate drug discovery. Traditionally, this has been through structure-guided lead optimization but high-throughput structural analyses can also be used to assist lead discovery, often by fragment-screening techniques.

X-ray, NMR and other biophysical techniques, as well as computational biology approaches such as virtual screening, are being exploited and candidate drugs developed in this way are in the clinic.

This symposium will discuss general principles of structure-guided drug discovery developed over the past decade. It will review recent developments in industry and academia for membrane targets, such as receptors and channels, and complex multiprotein systems involved in cell regulation and signaling, where protein-protein interactions and allosteric sites have often proved challenging. It will also review progress in targeting neglected diseases, particularly infectious diseases such as tuberculosis and malaria.

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