Analysis of free radicals, radical modifications and redox signalling

Venue: Aston Business School, Aston University

Location: Birmingham, United Kingdom

Event Date/Time: Apr 18, 2011 End Date/Time: Apr 19, 2011
Registration Date: Apr 15, 2011
Early Registration Date: Mar 18, 2011
Abstract Submission Date: Jan 31, 2011
Paper Submission Date: Jan 30, 2011
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Description

The importance of free radicals in biological systems has been recognized for many decades but until recently, was largely viewed as a deleterious aspect of inflammation and toxicity. However, strong evidence has now emerged that many radical modifications to biomolecules are reversible and have a regulatory role. In particular, the susceptibility of proteins for rapid and reversible free radical-mediated alterations in structure and function allows them to act as signalling intermediates that are sensitive to redox environment.


In view of the growing importance of redox signalling in biochemistry and pathology, the development of robust methods for accurate determination of cellular levels of free radicals and oxidants, as well analysis of biomolecule oxidation, is critical in the field. This meeting will focus on state of the art methodology for these areas, and discuss the limitations and pitfalls therein. The aims of the meeting are therefore to provide the participants with an enhanced understanding of (1) the best methods for measuring reactive oxygen species and nitrogen species, (2) modern approaches to detecting specific types of oxidative post-translational modifications, (3) methodology for analysis of lipid oxidation products with relevance to signalling. This focused meeting will be of prime importance to all researchers in the oxidative stress and redox signalling areas.

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