From beads on a string to the pearls of regulation: the structure and dynamics of chromatin. A joint

Venue: The Wellcome Trust Genome Campus

Location: Cambridge, United Kingdom

Event Date/Time: Aug 03, 2011 End Date/Time: Aug 04, 2011
Registration Date: Aug 02, 2011
Early Registration Date: Jul 04, 2011
Abstract Submission Date: Jun 01, 2011
Paper Submission Date: Jun 01, 2011
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Chromatin is widely recognised as playing many key roles in biology beyond serving as a tidy storage structure for DNA. In compacting the DNA, chromatin structure also influences key processes, including the expression of genetic information, the efficiency for mediating recovery from DNA damage, and the imprinting of gene expression status on daughter cells following cell division. The fundamental building block of chromatin organisation is the nucleosome. Higher order chromatin assembly is influenced by covalent modifications of the proteins at the nucleosome core, which act as platforms to recruit other proteins, and the underlying DNA sequence that influences nucleosome positioning.

The meeting will present advances in our understanding of chromatin structure and organization and the impact of these findings on our understanding of biological function. The meeting will bring together experts in the field to present recent advances in structural models for chromatin and the role of accessory factors that regulate its organisation. Topics to be covered will include the structure of the nucleosome core particle and the consequences resulting from histone modification and inclusion of histone variants, the analysis of nucleosome positioning in vivo and DNA sequence periodicities that influence location. Wider perspectives to be addressed include the relationship of chromatin and DNA repair, the role of high mobility group proteins and linker histones in chromatin organisation and function, and models for hierarchical assembly of chromatin. The meeting will mark the retirement of Professor Jean Thomas, who has made major contributions to the field.


Hinxton, Cambridgeshire
United Kingdom