Solubility & Solubilization in Aqueous Media (Solubility Course)

Venue: Westin La Paloma

Location: Tucson, Arizona, United States

Event Date/Time: May 02, 2011 End Date/Time: May 05, 2011
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The aim of this course is to provide a working knowledge of the various means of controlling the solubility and dissolution rate of a drug or other solute in an aqueous medium. While solubility and solubilization will be approached from both a conceptual and a practical point of view, emphasis will be placed upon the latter.

The first portion of this course is devoted to developing an understanding of the factors that govern solubility in both aqueous and nonaqueous solutions. This will lead to a simple and convenient means for estimating the aqueous solubility of organic compounds. The influence of both solute crystallinity and purity upon solubility will then be discussed along with the effects of various types of cosolutes, including impurities, carriers, and eutectics.

The bulk of the course is devoted to the various techniques available for enhancement of both solubility and dissolution rate in aqueous media. The most commonly used solubility enhancers (buffers, cosolvents, surfactants, and complexants) are each discussed in detail. A conceptual basis for understanding the degree of solubilization of a solute will be provided for each technique along with a large number of examples of its application. Each section is designed to provide the participants with a practical “how to” knowledge of the improvement of aqueous solubility. We will also cover the use of combinations of solubilizing agents and combinations of solubilization techniques.

The final day will provide an overview of solubilization by the various types of enhancers and suggests a strategy for the selection of the best means of solubilizing a particular solute. Several case studies will be used to illustrate the interrelationships among the various means of solubilization.


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