Venue: Boston

Location: Boston, United States

Event Date/Time: Jun 20, 2011 End Date/Time: Jun 21, 2011
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World Drug Transporter Summit
Using transporter information for intelligent drug development
Conference: 21st - 22nd June 2011 | Workshops: 20th June 2011 | Boston, MA
Membrane transporters are major determinants of drug safety and efficacy. It is vital that you know their role in the pharmacokinetic profiles of your candidates in order for them to be successful. You want to predict a compound’s behaviour before it enters the clinic in order to make those key decisions that will save time and money.
What do you need to discover about transporters to better understand how your drug is metabolised?
Attend the World Drug Transporter Summit to learn about:
Incorporating efflux transporters into in vivo/in vitro modeling to predict liver concentrations
• Using transporter information to build up the story of the molecule
• The use of SiRNA to inhibit OATPs, OAT substrate species and DDI potential
• Bottom-up mechanistic modeling using in vitro data to understand the role of transporters in ADME
• How disease effects transporter expression
• The changes to the industry since the publication of the ITC white paper
• Determining the influence of transporters at the blood-brain barrier, intestinal epithelia, and kidney proximal tubules with biological response
• How transporters in the kidney affect drug concentration, elimination and accumulation
And much more…
Early confirmed speakers include:
Toshihisa Ishikawa, Professor of Biochemistry & Molecular Biology, RIKEN Institute
Werner Kramer, Head of R&D, Germany, Sanofi-Aventis
Daniel A. Bow, Senior Research Pharmacologist, Abbott Laboratories
Matt Soars, Associate Principal Scientist, AstraZeneca
Peter Ward, Principal Scientist, Johnson & Johnson
Tristan Sissung, Staff Scientist, Clinical Medical Oncology Branch, National Institute of Health
Lassina Badolo, Principal Scientist, Lundbeck
Stephen Matthews, Chair, Department of Physiology, University of Toronto
Learn, Network and Discuss, we’ve worked with International Transporter Consortium, Genentech, Merck & Co, AstraZeneca, Abbott, Pfizer, GlaxoSmithKline, Eli Lilly and Johnson & Johnson to help you find reliable tools for predicting the role of transporters in the PK profiles of your drug candidates.

For more information or to register, simply:
Call: +1 212 537 5898