Students of tuberculosis have been interested in the immune response to M. tuberculosis since the modern understanding of the clinical disease. For decades the skin test response to tuberculin (TST) was the primary tool clinicians have had for study. With the development of Interferon Gamma Release Assays (IGRA) the recurrent question has been which is better, the TST or an IGRA. Hundreds of papers have been written on this matter and numerous guidelines have been issued. This conference will provide a solid framework within which to assess the rapidly moving field as well as provide a basis for making clinical decisions.