Lyophilization Process Development and Cycle Design - Webinar By ComplianceOnline (Biotech)
Venue: Online Event
|Event Date/Time: May 26, 2011||End Date/Time: May 26, 2011|
Optimized lyophilization cycle design can be an extremely difficult and daunting task for the scientist that is unskilled or under skilled in the process. This is becoming even more prevalent as many of the molecules coming out of discovery are more complex, unstable, and require a very specific, multi component formulation to impart not only good chemical stability and physical stability to the active ingredient, but also good physical stability to the dried solids themselves. Unfortunately, many of the molecules that are used to help stabilize the chemical and physical stability of the active ingredient, impart poor physical stability to the dried solids and can make lyophilization cycle design difficult.
Areas Covered in the Seminar:
- Thermal characterization including DSC and FDM.
- Understanding the effects of working with crystalline vs. amorphous components.
- The problem with working with a metastable glassy system and the use of annealing to correct this problem.
- Determining optimal shelf temperatures for the freezing step.
- Determining optimal shelf temperatures and chamber pressures for the primary drying step.
- Determining optimal shelf temperatures and chamber pressures for the secondary drying step.
- Characterization of the finished lyophilized product.
Who Will Benefit:
This webinar will provide valuable assistance to those companies involved in the handling of powders, lyophilized products, solid pharmaceutical dosage forms, and dried foods. Personnel who will benefit include:
- Quality Control Scientists
- Development Scientists
- Production Management
- Quality Assurance
NOTE: Use This Promocode ( 117660 ) To Get 10% Discount.