Simcyp focused workshop: Use of Simcyp in Drug Discovery
Venue: Copthorne Hotel
|Event Date/Time: Feb 08, 2012||End Date/Time: Feb 09, 2012|
Key aspects covered in this course:
â€¢ Prediction of Simcyp inputs from physicochemical properties
â€¢ Use of limited clearance data to prioritise compounds for further investigation (in vitro â€“ in vivo extrapolation (IVIVE))
â€¢ Consideration of drug-drug interaction potential of compounds
â€¢ Use of Simcyp animal modules for predicting exposure in toxicity studies (including use of the mechanistic Peff model that allows prediction of effective permeability from physicochemical properties alone)
â€¢ Prediction of tissue distribution from physicochemical data
â€¢ Selection of appropriate distribution models in human using
The course is ideal for scientists working in DMPK drug discovery departments.
The Simcyp Population-based Simulator and Simcyp Animal Simulators will be used throughout the workshops. Delegates will be guided through the hands-on exercises, so prior experience with the Simcyp Simulator is not required; however, advanced Simcyp users will benefit from exploring the science and specific algorithms in more depth through discussions with tutors and peers.