Simcyp Focused Workshop: Transporters

Venue: Copthorne Hotel

Location: Sheffield, United Kingdom

Event Date/Time: Feb 15, 2012 End Date/Time: Feb 16, 2012
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Key aspects covered in the course:
• Re-visiting common in vitro transporter-based assays
• Characterisation of key parameters required to model in vitro data
• Understanding complex data sets generated from in vitro assays
• Approaches to optimising & modelling complex data sets derived from in vitro assays
• Scaling of in vitro data for gut, liver, brain and kidney to in vivo
• Practical examples involving the applications of the modelling approach to answer observations related to
o Oral bioavailability
o Hepatic clearance
o Brain disposition
o Renal clearance
o Drug-drug interactions (DDI)
• Predicting the impact of transporters on tissue-drug concentrations (efficacy/toxicity)
• Impact of population variability on transporter-based drug disposition
• Approaches to handling genetic variations
• Modelling the impact of transporters on pharmacodynamics
The course is ideal for modellers and scientists (both bench & clinical) who want to enhance their knowledge of mechanistic approaches to predicting the impact of drug transport proteins on ADME/pharmacokinetics & toxicity.
The Simcyp Population-based Simulator and Microsoft Excel will be used throughout the workshop. Delegates will be guided through the hands-on exercises, so prior experience with the Simcyp Simulator is not required; however, advanced Simcyp users will benefit from exploring the science and specific algorithms in more depth through discussions with tutors and peers.