Simcyp Focused Workshop: Paediatrics

Venue: Copthorne Hotel

Location: Sheffield, United Kingdom

Event Date/Time: Mar 14, 2012 End Date/Time: Mar 15, 2012
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Description

Participants will learn how pharmacokinetic (PK) behaviour can be modelled in neonates, infants and children and how it can be linked to pharmacodynamics (PD). Hands-on exercises explore how this valuable information is relevant to early and informed decisions to assist in the improved design of paediatric clinical studies
Key aspects covered in this course:
• The impact of developmental physiology and ontogeny of drug elimination systems
• How changing ontogeny influences the level of drug-drug interactions in paediatrics
• In vitro – in vivo extrapolation (IVIVE) and how it applies to neonates, infants and children.
• Development and utilisation of a paediatric full physiologically-based pharmacokinetic (PBPK) model
• How the PBPK model can be linked to PD
• The role of modelling and simulation in paediatric drug development

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