Simcyp Focused Workshop: Paediatrics

Venue: Copthorne Hotel

Location: Sheffield, United Kingdom

Event Date/Time: Mar 14, 2012 End Date/Time: Mar 15, 2012
Report as Spam


Participants will learn how pharmacokinetic (PK) behaviour can be modelled in neonates, infants and children and how it can be linked to pharmacodynamics (PD). Hands-on exercises explore how this valuable information is relevant to early and informed decisions to assist in the improved design of paediatric clinical studies
Key aspects covered in this course:
• The impact of developmental physiology and ontogeny of drug elimination systems
• How changing ontogeny influences the level of drug-drug interactions in paediatrics
• In vitro – in vivo extrapolation (IVIVE) and how it applies to neonates, infants and children.
• Development and utilisation of a paediatric full physiologically-based pharmacokinetic (PBPK) model
• How the PBPK model can be linked to PD
• The role of modelling and simulation in paediatric drug development