Simcyp Focused Workshop: Parameter Estimation and Pharmacodynamics
Venue: Copthorne Hotel
|Event Date/Time: May 29, 2012||End Date/Time: May 30, 2012|
Key aspects covered in this course:
â€¢ The theoretical basis for combining bottom-up and top-down modelling and simulation
â€¢ Use of minimal and full PBPK models to describe pharmacokinetics
â€¢ Parameter estimation:
Background and available algorithms
Step-by step guidance on data entry, fitting and interpretation of results
Simultaneous fitting of PK and PD parameters
The models available
The use of preliminary clinical data to model and simulate various covariate effects (e.g. genotypic/phenotypic differences, effects of diseases such as renal impairment or cirrhosis)
PD at the relevant effect site e.g. brain
as part of the Simcyp focused workshop series:
A systems pharmacology approach to modelling and simulation: Accelerating model building and covariate recognition in drug development by combining top-down and bottom-up modelling of pharmacokinetics linked to drug response.
29th & 30th May 2012
Sheffield United Football Club
Two day hands-on course
The course is ideal for pharmacometricians and clinical pharmacologists.
The Simcyp Population-based Simulator and its parameter estimation module will be used throughout the workshops. Delegates will be guided through the hands-on exercises, so prior experience with the Simcyp Simulator is not required; however, some familiarity with fitting tools such as WinNonlin would be advantageous.