Simcyp Focused Workshop: Parameter Estimation and Pharmacodynamics

Venue: Copthorne Hotel

Location: Sheffield, United Kingdom

Event Date/Time: May 29, 2012 End Date/Time: May 30, 2012
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Description

The workshop covers the concepts and the practical applications of integrating in vitro data and physiological knowledge with clinical observations for the purpose of estimating unknown/uncertain model parameters. Delegates will work through different parameter estimation examples using fitting tools and explore various pharmacodynamic (PD) models.
Key aspects covered in this course:
• The theoretical basis for combining bottom-up and top-down modelling and simulation
• Use of minimal and full PBPK models to describe pharmacokinetics
• Parameter estimation:
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Background and available algorithms
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Step-by step guidance on data entry, fitting and interpretation of results
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Simultaneous fitting of PK and PD parameters
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Covariate recognition
• Pharmacodynamics:
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The models available
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The use of preliminary clinical data to model and simulate various covariate effects (e.g. genotypic/phenotypic differences, effects of diseases such as renal impairment or cirrhosis)
o
PD at the relevant effect site e.g. brain
as part of the Simcyp focused workshop series:
A systems pharmacology approach to modelling and simulation: Accelerating model building and covariate recognition in drug development by combining top-down and bottom-up modelling of pharmacokinetics linked to drug response.
29th & 30th May 2012
Copthorne Hotel
Sheffield United Football Club
Two day hands-on course
The course is ideal for pharmacometricians and clinical pharmacologists.
The Simcyp Population-based Simulator and its parameter estimation module will be used throughout the workshops. Delegates will be guided through the hands-on exercises, so prior experience with the Simcyp Simulator is not required; however, some familiarity with fitting tools such as WinNonlin would be advantageous.

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