Cell Based Assays 2012

Venue: London

Location: London, United Kingdom

Event Date/Time: Jun 26, 2012 End Date/Time: Jun 27, 2012
Registration Date: Jun 24, 2012
Early Registration Date: May 15, 2012
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Description

Cell Based Assays 2012

26th -27th June 2012 London UK





Cell Based Assays Conference is a much awaited symposium where latest developments on cell based assays and their significance to the strategic future of Research and Development in pharmaceutical industry etc will be discussed and debated. Here in Cell Based Assays Conference keynote speakers like Eberhard Krausz, Marianthi Papakosta, Marie H. Delmotte, Dr. Peter Horvath, Professor Marc Bickle etc will come and provide latest updates on cell based assays. Plenary sessions, debates and discussions will be very much beneficial



Key Speakers



Eberhard Krausz, Director, Assay Development & Target Validation, Enabling Biology, Janssen Research & Development



Marianthi Papakosta Scientific Director at Grunenthal GmbH



Marie H. Delmotte Lab Head - Cellular and Molecular Biology at Novartis



Dr. Xavier Leroy Project Promoter & Leader Associate Director Drug Discovery Dept. Actelion Pharmaceuticals Ltd



Dr. Jeroen van Bergeijk GPRD Research Neuroscience Molecular Biology & Biochemistry Abbott GmbH & Co. KG



Thomas Koblizek Senior Scientist R&D Lonza



Dr. Peter Horvath, Head of image and data analysis, ETH Zurich, Light Microscopy Centre.



Professor Marc Bickle Head of Technology Development Studio at Max Planck Institute of Molecular Cell Biology and Genetics



Remko de Pril Team Leader Target Discovery and High-Content Screening Galapagos



Professor David R. Greaves Professor of Inflammation Biology Sir William Dunn School of Pathology University of Oxford



Robin Ketteler MRC LMCB University College London



Rachel Russell Director and Head of the Plate Based Pharmacology Department Pfizer










Cell Based Assays 2012

Day 1 26th June 2012


09:00 Registration and refreshments



09:30 Opening address from the Chair



09:40 Quantitative analysis of cell-based high-content drug and siRNA screens - How can machine intelligence help?

Image quality enhancement (vignetting)

Image analysis of end point- and time-resolved data (segmentation, feature extraction, tracking)
Multi-parametric analysis of single cell-based assays using machine learning (classification, regression, method optimization, weakly-supervised approaches)

Statistical analysis and quality control issues

Dr. Peter Horvath, Head of image and data analysis, ETH Zurich, Light Microscopy Centre



10:20 Systematic analysis of complex signal transduction pathways using protein fragment complementation assays

Protein:protein interactions
Classical GPCR signaling
Non-classical GPCR pathways and interconnectivity
Examples for complex networks
The PCA working principle
Some PCA examples
Somatostatin homodimers/heterodimer data
CXCR4 agonist/antagonist data

Thomas Koblizek Senior Scientist R&D Lonza

11:00 Morning refreshments



11:20 Use of cell based GPCR assays to identify novel CB2 agonists and chemokine receptor antagonists

David R. Greaves Professor of Inflammation Biology Sir William

Dunn School of Pathology University of Oxford



12:00 Sponsor Speaking section contact tareef.ahmed@atta-online.co.uk for more detail



12:40 Networking lunch



13:40 Targeting endogenous stem cells for therapy

Targeting endogenous stem cells for therapy and related approaches (e.g. IPSCs).

Recruitment of (neuronal) stem and precursor cells for regeneration & neuroprotection

Targeting cancer stem cells for oncology

Hedgehog signaling

Dr. Jeroen van Bergeijk GPRD Research Neuroscience Molecular Biology & Biochemistry Abbott GmbH & Co. KG



14:20 Carcinogenicity risk assessment of Biologics using in vitro cell-based assays
Marie H. Delmotte Lab Head - Cellular and Molecular Biology at Novartis



15:00 Afternoon Refreshments



15:20 Sponsor Speaking section contact tareef.ahmed@atta-online.co.uk for more detail



16:00 Pores for thought; analyses of TRPV1 chimeras using a bespoke heat activation assay, demonstrate that differences in the pore domain confer species specific pharmacological sensitivity

Marianthi Papakosta Scientific Director at Grunenthal GmbH



16:40 Closing remarks from the Chair



16:50 Networking drinks

Take your discussions further and build new relationships in a relaxed and informal setting





Cell Based Assays 2012





Day2 27th June 2012





09:00 Registration and refreshments



09:30 Opening address from the Chair



09:40 Primary cells and 3D models in high-throughput screening



Robin Ketteler MRC LMCB University College London



10:20 Polarity markers as functional readouts of hepatic toxicity in 3D

use of bacterial artificial chromosome to ensure physiological levels of tpj1-cherry polarity marker expression
3 dimensional cell culture to ensure polarity and functional bile canaliculi system
generation of transgenic animals for primary cell culture
high throughput imaging of live polarised hepatocytes
automated image analysis

Marc Bickle Head of Technology Development Studio at Max Planck Institute of Molecular Cell Biology and Genetics



11:00 Morning refreshments



11:20 Application of in vitro 3D models for drug discovery








More complex and therefore physiologically more relevant cell-based assays will ultimately be more predictive than current 2D-based assays.

Technologies and assay set-up for medium-throughput compound screening in 3D (co-) cultures

High-content analysis is a versatile technology platform to capture complex cell-based assays.

Applications in oncology, virology and safety pharmacology



Eberhard Krausz, Director, Assay Development & Target Validation, Enabling Biology, Janssen Research & Development




12:00 Sponsor Speaking section contact tareef.ahmed@atta-online.co.uk for more detail




12:40 Networking lunch



13:40 plate based screening

Gene expression assay

Label-free as well as assay development

native neuronal cell types

Presentation from Pfizer



14:20 Beta-Arrestin 2 in Drug Discovery

Deorphanisation
HTS
Biased signaling
Scavanger
In-vitro to in-vivo
Xavier Leroy, Ph.D. Project Promoter & Leader Associate Director Drug Discovery Dept. Actelion Pharmaceuticals Ltd



15:00 Afternoon Refreshments



15:20 Sponsor Speaking section contact tareef.ahmed@atta-online.co.uk for more detail



16:00 High-Content screen for inhibitors of cell migration in cancer metastasis using adenoviral knock-down

high-throughput wound healing assay to identify novel genes involved in metastatic cell migration.

Genes whose knock-down inhibit cell migration

effect on the open wound

Remko de Pril Galapagos Team Leader Target Discovery and High-Content Screening



16:40 Closing remarks from the Chair



16:50 End of Day 2





Registration Form for Cell Based Assays 2012

24th-25th April 2012, London UK.



Standard Prices £499
Price for Academic, NGO and Government £299GROUP DISCOUNTS AVAILABLE

The conference fee includes refreshments, lunch, conference papers and access to the Document Portal containing all of the presentations.



Promotional Literature Distribution: Distribute of your company’s promotional literature to all conference attendees for £499+VAT

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tareef.ahmed@atta-online.co.uk



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