Event Date/Time: Sep 20, 2012 | End Date/Time: Sep 21, 2012 |
Registration Date: Sep 08, 2012 |
Description
Use of Simcyp in Drug Discovery
Case study based workshop focusing on using the dynamic models in the Simcyp Simulator to prioritise compounds based on data available in early drug discovery
Absorption
Predicting oral drug bioavailability and its inter- individual variability: Interplay between formulation, drug permeability and metabolism using the Simcyp Advanced Dissolution, Absorption and Metabolism (ADAM) model
Transporters
The ABC of modelling drug transporter data: Mechanistic approaches to predict the impact of drug transport proteins on ADME/pharmacokinetics & toxicity
Parameter Estimation and Pharmacodynamics
A systems pharmacology approach to modelling and simulation: Accelerating model building and covariate recognition in drug development by combining top-down and bottom-up modelling of pharmacokinetics linked to drug response
Paediatrics
Predicting age related changes to pharmacokinetics and drug-drug interactions including associated variability: Linking this information to drug response in the paediatric population